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Publications

Full bibliography

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Preservation of fecal microbiome is associated with reduced severity of Graft-versus-Host Disease.

 

Burgos da Silva M, Ponce DM, Dai A, Devlin S, Gomes A, Moore G, Slingerland J, Shouval R, Armijo GK, De Wolf S, Fei F, Fontana E, Amoretti LA, Wright RJ, Andrlová H, Miltiadous O, Perales MA, Taur Y, Peled JU*,

 

Blood 2022

Vitamin D Insufficiency and Clinical Outcomes with Chimeric Antigen Receptor T-Cell Therapy in Large B-cell Lymphoma: Vitamin D insufficiency and CAR-T in LBCL.

 

Nath K, Alarcon Tomas A, Flynn, J, Fein JA, Alperovich A, Anagnostou T, Lee Batlevi C, Dahi PB, Fingrut WB, Giralt SA, Lin RJ, Palomba LM, Peled JU, Salles G, Sauter CS, Scordo M, Fraint E, Feuer E, Shah N, Slingerland J, Devlin S, Shah GL, Gupta G, Perales MA, Shouval R.

 

Transplant Cell Ther 2022

MAIT and Vδ2 unconventional T cells are supported by a diverse intestinal microbiome and correlate with favorable patient outcome after allogeneic HCT.

 

Andrlová H, Miltiadous O, Kousa AI, Dai A, DeWolf S, Violante S, Park, H-Y, Janaki-Raman S, Gardner R, El Daker S, Slingerland J, Giardina P, Clurman A, GomesALC, Nguyen C, da Silva MB, Armijo GK, Lee N, Zappasodi R, Chaligne R, Masilionis, Fontana E, Ponce D, Cho C, Bush A, Hill L, Chao N, Sung AD, Giralt SA, Vidal EH, Hosszu KK, Devlin SM, Peled JU, Cross JR, Perales MA, Godfrey DI, van den Brink MRM, Markey KA

 

Sci Transl Med, 2022

A compilation of fecal microbiome shotgun metagenomics from hematopoietic cell transplantation patients. 

 

Yan J, Liao C, Taylor BP, Fontana E, Amoretti LA, Wright RJ, Littmann ER, Dai A, Waters N, Peled JU*, Taur Y, Perales MA, Siranosian BA, Bhatt AS, van den Brink MRM, Pamer EG, Schluter J, Xavier JB. 

 

Sci Data, 2022

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Early intestinal microbial features are associated with CD4 T-cell recovery after allogeneic hematopoietic transplant. 

 

Miltiadous O, Waters NR, Andrlová H, Dai A, Nguyen CL, Burgos da Silva M, Lindner S, Slingerland J, Giardina P, Clurman A, Armijo GK, Gomes ALC, Lakkaraja M, Maslak P, Scordo M, Shouval R, Staffas A, O'Reilly R, Taur Y, Prockop S, Boelens JJ, Giralt S, Perales MA, Devlin SM, Peled JU, Markey KA, van den Brink MRM. 

 

Blood, 2022

Alloreactive T cells deficient of the short-chain fatty acid receptor GPR109A induce less graft-versus-host disease.

 

GK, Shono Y, Nguyen C, Monette S, Dwomoh E, Lee N, Geary CD, Perobelli SM, Smith M, Markey KA, Vardhana SA, Kousa AI, Zamir E, Greenfield I, Sun JC, Cross JR, Peled JU, Jenq RR, Stein-Thoeringer CK, van den Brink MRM.

 

Blood, 2022

Compositional Flux Within the Intestinal Microbiota and Risk for Bloodstream Infection With Gram-negative Bacteria. 

 

​Stoma I, Littmann ER, Peled JU, Giralt S, van den Brink MRM, Pamer EG, Taur Y.

 

Clinical Infectious Diseases, 2021 

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Haematopoietic cell transplantation outcomes are linked to intestinal mycobiota dynamics and an expansion of Candida parapsilosis complex species. 

 

Rolling T, Zhai B, Gjonbalaj M, Tosini N, Yasuma-Mitobe K, Fontana E, Amoretti LA, Wright RJ, Ponce DM, Perales MA, Xavier JB, van den Brink MRM, Markey KA, Peled JU, Taur Y, Hohl TM.

 

Nat Microbiol, 2021

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The Detrimental Effects of Oral Vancomycin. 

 

Peled JU, Taur Y.

 

Clinical Infectious Diseases, 2021 

A phase 2 trial of the somatostatin analog pasireotide to prevent GI toxicity and acute GVHD in allogeneic hematopoietic stem cell transplant. 

 

Ramalingam S, Siamakpour-Reihani S, Bohannan L, Ren Y, Sibley A, Sheng J, Ma L, Nixon AB, Lyu J, Parker DC, Bain J, Muehlbauer M, Ilkayeva O, Kraus VB, Huebner JL, Spitzer T, Brown J, Peled JU, van den Brink M, Gomes A, Choi T, Gasparetto C, Horwitz M, Long G, Lopez R, Rizzieri D, Sarantopoulos S, Chao N, Sung AD.

 

PLoS One, 2021

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Fecal microbiota diversity disruption and clinical outcomes after auto-HCT: a multicenter observational study. 

 

Khan N, Lindner S, Gomes ALC, Devlin SM, Shah GL, Sung AD, Sauter CS, Landau HJ, Dahi PB, Perales MA, Chung DJ, Lesokhin AM, Dai A, Clurman A, Slingerland JB, Slingerland AE, Brereton DG, Giardina PA, Maloy M, Armijo GK, Rondon-Clavo C, Fontana E, Bohannon L, Ramalingam S, Bush AT, Lew MV, Messina JA, Littmann E, Taur Y, Jenq RR, Chao NJ, Giralt S, Markey KA, Pamer EG, van den Brink MRM, Peled JU.

 

Blood, 2021

Compilation of longitudinal microbiota data and hospitalome from hematopoietic cell transplantation patients. 

 

Liao C, Taylor BP, Ceccarani C, Fontana E, Amoretti LA, Wright RJ, Gomes ALC, Peled JU, Taur Y, Perales MA, van den Brink MRM, Littmann E, Pamer EG, Schluter J, Xavier JB. 

 

Sci Data, 2021

Chlorhexidine Gluconate Bathing Reduces the Incidence of Bloodstream Infections in Adults Undergoing Inpatient Hematopoietic Cell Transplantation. 

 

​Giri VK, Kegerreis KG, Ren Y, Bohannon LM, Lobaugh-Jin E, Messina JA, Matthews A, Mowery YM, Sito E, Lassiter M, Saullo JL, Jung SH, Ma L, Greenberg M, Andermann TM, van den Brink MRM, Peled JU, Gomes ALC, Choi T, Gasparetto CJ, Horwitz ME, Long GD, Lopez RD, Rizzieri DA, Sarantopoulos S, Chao NJ, Allen DH, Sung AD.

 

Transplant Cell Ther, 2021

High progression-free survival after intermediate intensity double unit cord blood transplantation in adults. 

 

Barker JN, Devlin SM, Naputo KA, Skinner K, Maloy MA, Flynn L, Anagnostou T, Avecilla ST, Scaradavou A, Cho C, Dahi PB, Giralt SA, Gyurkocza B, Hanash AM, Hsu K, Jakubowski AA, Papadopoulos EB, Peled JU, Perales MA, Sauter CS, Shah GL, Shaffer BC, Tamari R, Young JW, Roshal M, O'Reilly RJ, Ponce DM, Politikos I.

 

Blood Adv, 2020

Monocyte Reconstitution and Gut Microbiota Composition after Hematopoietic Stem Cell Transplantation. 

 

Morjaria S, Zhang AW, Kim S, Peled JU, Becattini S, Littmann ER, Pamer EG, Abt MC, Perales MA.

 

Clin Hematol Int, 2020

Favorable outcomes of COVID-19 in recipients of hematopoietic cell transplantation. 

 

Shah GL, DeWolf S, Lee YJ, Tamari R, Dahi PB, Lavery JA, Ruiz J, Devlin SM, Cho C, Peled JU, Politikos I, Scordo M, Babady NE, Jain T, Vardhana S, Daniyan A, Sauter CS, Barker JN, Giralt SA, Goss C, Maslak P, Hohl TM, Kamboj M, Ramanathan L, van den Brink MR, Papadopoulos E, Papanicolaou G, Perales MA.

 

J Clin Inves,. 2020 

The gut microbiota is associated with immune cell dynamics in humans. 

 

Schluter J, Peled JU, Taylor BP, Markey KA, Smith M, Taur Y, Niehus R, Staffas A, Dai A, Fontana E, Amoretti LA, Wright RJ, Morjaria S, Fenelus M, Pessin MS, Chao NJ, Lew M, Bohannon L, Bush A, Sung AD, Hohl TM, Perales MA, van den Brink MRM, Xavier JB.

 

Nature, 2020

Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites.

 

Guo H, Chou WC, Lai Y, Liang K, Tam JW, Brickey WJ, Chen L, Montgomery ND, Li X, Bohannon LM, Sung AD, Chao NJ, Peled JU, Gomes ALC, van den Brink MRM, French MJ, Macintyre AN, Sempowski GD, Tan X, Sartor RB, Lu K, Ting JPY.

 

Science, 2020

Accelerated single cell seeding in relapsed multiple myeloma.

 

Landau HJ, Yellapantula V, Diamond BT, Rustad EH, Maclachlan KH, Gundem G, Medina-Martinez J, Ossa JA, Levine MF, Zhou Y, Kappagantula R, Baez P, Attiyeh M, Makohon-Moore A, Zhang L, Boyle EM, Ashby C, Blaney P, Patel M, Zhang Y, Dogan A, Chung DJ, Giralt S, Lahoud OB, Peled JU, Scordo M, Shah G, Hassoun H, Korde NS, Lesokhin AM, Lu S, Mailankody S, Shah U, Smith E, Hultcrantz ML, Ulaner GA, van Rhee F, Morgan GJ, Landgren O, Papaemmanuil E, Iacobuzio-Donahue C, Maura F

 

Nat Commun, 2020

The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD. 

 

Markey KA, Schluter J, Gomes ALC, Littmann ER, Pickard AJ, Taylor BP, Giardina PA, Weber D, Dai A, Docampo MD, Armijo GK, Slingerland AE, Slingerland JB, Nichols KB, Brereton DG, Clurman AG, Ramos RJ, Rao A, Bush A, Bohannon L, Covington M, Lew MV, Rizzieri DA, Chao N, Maloy M, Cho C, Politikos I, Giralt S, Taur Y, Pamer EG, Holler E, Perales MA, Ponce DM, Devlin SM, Xavier J, Sung AD, Peled JU, Cross JR, van den Brink MRM. 

 

Blood, 2020

 Microbiota and Allogeneic Hematopoietic-Cell Transplantation. 

 

Peled JU, Gomes ALC, van den Brink MRM.

 

N Engl J Med, 2020

An alpha-defensin gene single nucleotide polymorphism modulates the gut microbiota and may alter the risk of acute graft-versus-host disease. 

 

Rashidi A, Herman A, Gomes ALC, Peled JU, Jenq RR, Brereton DG, Staley C, Blazar BR, Weisdorf DJ.

 

Br J Haematol, 2020

Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation. 

 

Peled JU, Gomes ALC, Devlin SM, Littmann ER, Taur Y, Sung AD, Weber D, Hashimoto D, Slingerland AE, Slingerland JB, Maloy M, Clurman AG, Stein-Thoeringer CK, Markey KA, Docampo MD, Burgos da Silva M, Khan N, Gessner A, Messina JA, Romero K, Lew MV, Bush A, Bohannon L, Brereton DG, Fontana E, Amoretti LA, Wright RJ, Armijo GK, Shono Y, Sanchez-Escamilla M, Castillo Flores N, Alarcon Tomas A, Lin RJ, Yáñez San Segundo L, Shah GL, Cho C, Scordo M, Politikos I, Hayasaka K, Hasegawa Y, Gyurkocza B, Ponce DM, Barker JN, Perales MA, Giralt SA, Jenq RR, Teshima T, Chao NJ, Holler E, Xavier JB, Pamer EG, van den Brink MRM.

 

N Engl J Med, 2020

Therapeutics Targeting the Gut Microbiome: Rigorous Pipelines for Drug Development. 

 

Markey KA, van den Brink MRM, Peled JU.

 

Cell Host Microbe, 2020

High-resolution mycobiota analysis reveals dynamic intestinal translocation preceding invasive candidiasis. 

 

Zhai B, Ola M, Rolling T, Tosini NL, Joshowitz S, Littmann ER, Amoretti LA, Fontana E, Wright RJ, Miranda E, Veelken CA, Morjaria SM, Peled JU, van den Brink MRM, Babady NE, Butler G, Taur Y, Hohl TM.

 

Nat Med, 2020

Lactose drives Enterococcus expansion to promote graft-versus-host disease. 

 

Stein-Thoeringer CK, Nichols KB, Lazrak A, Docampo MD, Slingerland AE, Slingerland JB, Clurman AG, Armijo G, Gomes ALC, Shono Y, Staffas A, Burgos da Silva M, Devlin SM, Markey KA, Bajic D, Pinedo R, Tsakmaklis A, Littmann ER, Pastore A, Taur Y, Monette S, Arcila ME, Pickard AJ, Maloy M, Wright RJ, Amoretti LA, Fontana E, Pham D, Jamal MA, Weber D, Sung AD, Hashimoto D, Scheid C, Xavier JB, Messina JA, Romero K, Lew M, Bush A, Bohannon L, Hayasaka K, Hasegawa Y, Vehreschild MJGT, Cross JR, Ponce DM, Perales MA, Giralt SA, Jenq RR, Teshima T, Holler E, Chao NJ, Pamer EG, Peled JU, van den Brink MRM.

 

Science, 2019

Antibiotic-Induced Shifts in Fecal Microbiota Density and Composition during Hematopoietic Stem Cell Transplantation. 

 

Morjaria S, Schluter J, Taylor BP, Littmann ER, Carter RA, Fontana E, Peled JU, van den Brink MRM, Xavier JB, Taur Y.

​

Infect Immun, 2019

Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus. 

 

Kim SG, Becattini S, Moody TU, Shliaha PV, Littmann ER, Seok R, Gjonbalaj M, Eaton V, Fontana E, Amoretti L, Wright R, Caballero S, Wang ZX, Jung HJ, Morjaria SM, Leiner IM, Qin W, Ramos RJJF, Cross JR, Narushima S, Honda K, Peled JU, Hendrickson RC, Taur Y, van den Brink MRM, Pamer EG.

 

Nature, 2019

Minimal residual disease negativity in multiple myeloma is associated with intestinal microbiota composition. 

 

Pianko MJ, Devlin SM, Littmann ER, Chansakul A, Mastey D, Salcedo M, Fontana E, Ling L, Tavitian E, Slingerland JB, Slingerland AE, Clurman A, Gomes ALC, Taur Y, Pamer EG, Peled JU, van den Brink MRM, Landgren O, Lesokhin AM. 

​

Blood Adv, 2019 

Diversification and Evolution of Vancomycin-Resistant Enterococcus faecium during Intestinal Domination. 

 

Dubin KA, Mathur D, McKenney PT, Taylor BP, Littmann ER, Peled JU, van den Brink MRM, Taur Y, Pamer EG, Xavier JB.

 

Infect Immun, 2019

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Genome-Wide Screening for Enteric Colonization Factors in Carbapenem-Resistant ST258 Klebsiella pneumoniae. 

​

Jung HJ, Littmann ER, Seok R, Leiner IM, Taur Y, Peled J, van den Brink M, Ling L, Chen L, Kreiswirth BN, Goodman AL, Pamer EG.

 

mBio, 2019

Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification.

 

Sorbara MT, Dubin K, Littmann ER, Moody TU, Fontana E, Seok R, Leiner IM, Taur Y, Peled JU, van den Brink MRM, Litvak Y, Bäumler AJ, Chaubard JL, Pickard AJ, Cross JR, Pamer EG. 

 

J Exp Med, 2019

Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease. 

 

Zhao D, Kim YH, Jeong S, Greenson JK, Chaudhry MS, Hoepting M, Anderson ER, van den Brink MR, Peled JU, Gomes AL, Slingerland AE, Donovan MJ, Harris AC, Levine JE, Ozbek U, Hooper LV, Stappenbeck TS, Ver Heul A, Liu TC, Reddy P, Ferrara JL.

 

J Clin Invest, 2018

Reconstitution of the gut microbiota of antibiotic-treated patients by autologous fecal microbiota transplant. 

 

​Taur Y, Coyte K, Schluter J, Robilotti E, Figueroa C, Gjonbalaj M, Littmann ER, Ling L, Miller L, Gyaltshen Y, Fontana E, Morjaria S, Gyurkocza B, Perales MA, Castro-Malaspina H, Tamari R, Ponce D, Koehne G, Barker J, Jakubowski A, Papadopoulos E, Dahi P, Sauter C, Shaffer B, Young JW, Peled J, Meagher RC, Jenq RR, van den Brink MRM, Giralt SA, Pamer EG, Xavier JB.

 

Sci Transl Med, 2018

The Microbiome and Hematopoietic Cell Transplantation: Past, Present, and Future.

 

Andermann TM, Peled JU, Ho C, Reddy P, Riches M, Storb R, Teshima T, van den Brink MRM, Alousi A, Balderman S, Chiusolo P, Clark WB, Holler E, Howard A, Kean LS, Koh AY, McCarthy PL, McCarty JM, Mohty M, Nakamura R, Rezvani K, Segal BH, Shaw BE, Shpall EJ, Sung AD, Weber D, Whangbo J, Wingard JR, Wood WA, Perales MA, Jenq RR, Bhatt AS. 

 

Biol Blood Marrow Transplant, 2018

Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT.

 

Haak BW, Littmann ER, Chaubard JL, Pickard AJ, Fontana E, Adhi F, Gyaltshen Y, Ling L, Morjaria SM, Peled JU, van den Brink MR, Geyer AI, Cross JR, Pamer EG, Taur Y.

 

Blood, 2018.

Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice.

 

Staffas A, Burgos da Silva M, Slingerland AE, Lazrak A, Bare CJ, Holman CD, Docampo MD, Shono Y, Durham B, Pickard AJ, Cross JR, Stein-Thoeringer C, Velardi E, Tsai JJ, Jahn L, Jay H, Lieberman S, Smith OM, Pamer EG, Peled JU, Cohen DE, Jenq RR, van den Brink MRM. 

 

Cell Host Microbe, 2018

Third-party fecal microbiota transplantation following allo-HCT reconstitutes microbiome diversity.

 

DeFilipp Z, Peled JU, Li S, Mahabamunuge J, Dagher Z, Slingerland AE, Del Rio C, Valles B, Kempner ME, Smith M, Brown J, Dey BR, El-Jawahri A, McAfee SL, Spitzer TR, Ballen KK, Sung AD, Dalton TE, Messina JA, Dettmer K, Liebisch G, Oefner P, Taur Y, Pamer EG, Holler E, Mansour MK, van den Brink MRM, Hohmann E, Jenq RR, Chen YB.

 

Blood Adv, 2018

Unlocking the Complex Flavors of Dysgeusia after Hematopoietic Cell Transplantation.

 

Scordo M, Shah GL, Peled JU, Preston EV, Buchan ML, Epstein JB, Barasch A, Giralt SA. 

 

Biol Blood Marrow Transplant, 2018

Intestinal Microbiota and Relapse After Hematopoietic-Cell Transplantation. 

 

Peled JU, Devlin SM, Staffas A, Lumish M, Khanin R, Littmann ER, Ling L, Kosuri S, Maloy M, Slingerland JB, Ahr KF, Porosnicu Rodriguez KA, Shono Y, Slingerland AE, Docampo MD, Sung AD, Weber D, Alousi AM, Gyurkocza B, Ponce DM, Barker JN, Perales MA, Giralt SA, Taur Y, Pamer EG, Jenq RR, van den Brink MRM. 

 

J Clin Oncol., 2017

Microbiota Disruption Induced by Early Use of Broad-Spectrum Antibiotics Is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation.

 

Weber D, Jenq RR, Peled JU, Taur Y, Hiergeist A, Koestler J, Dettmer K, Weber M, Wolff D, Hahn J, Pamer EG, Herr W, Gessner A, Oefner PJ, van den Brink MRM, Holler E.

 

Biol Blood Marrow Transplant, 2017 

Role of the intestinal mucosa in acute gastrointestinal GVHD. 

 

Peled JU, Hanash AM, Jenq RR.

 

Hematology Am Soc Hematol Educ Program, 2016

Role of the intestinal mucosa in acute gastrointestinal GVHD. 

 

Peled JU, Hanash AM, Jenq RR.

 

Blood, 2016 

Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice. 

​

Shono Y, Docampo MD, Peled JU, Perobelli SM, Velardi E, Tsai JJ, Slingerland AE, Smith OM, Young LF, Gupta J, Lieberman SR, Jay HV, Ahr KF, Porosnicu Rodriguez KA, Xu K, Calarfiore M, Poeck H, Caballero S, Devlin SM, Rapaport F, Dudakov JA, Hanash AM, Gyurkocza B, Murphy GF, Gomes C, Liu C, Moss EL, Falconer SB, Bhatt AS, Taur Y, Pamer EG, van den Brink MRM, Jenq RR.

 

Sci Transl Med, 2016

Role of gut flora after bone marrow transplantation. 

 

Peled JU, Jenq RR, Holler E, van den Brink MR.

 

Nat Microbiol, 2016.

Intestinal Blautia Is Associated with Reduced Death from Graft-versus-Host Disease. 

 

Jenq RR, Taur Y, Devlin SM, Ponce DM, Goldberg JD, Ahr KF, Littmann ER, Ling L, Gobourne AC, Miller LC, Docampo MD, Peled JU, Arpaia N, Cross JR, Peets TK, Lumish MA, Shono Y, Dudakov JA, Poeck H, Hanash AM, Barker JN, Perales MA, Giralt SA, Pamer EG, van den Brink MR.

 

Biol Blood Marrow Transplant, 2015

Intestinal microbiota-related effects on graft-versus-host disease.

 

Shono Y, Docampo MD, Peled JU, Perobelli SM, Jenq RR. 

 

Int J Hematol, 2015

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